Senior Director DMPK

We are seeking an experienced, creative and highly motivated expert with industry research experience in DMPK focused on small molecule lead optimization for discovery research programs, preclinical and clinical drug development. In addition to overseeing a group of external professionals, this position will be responsible for leading DMPK interactions with medicinal chemists to facilitate the successful achievement of lead optimization programs and the rapid and efficient progression of drug candidates in preclinical development. Specific responsibilities include, but are not limited to: Supervise and mentor a group of external DMPK scientists supporting multiple drug discovery programs. Provide scientific guidance on chemical lead optimization programs and work in close collaboration with medicinal chemists to optimize the DMPK properties of candidate drugs. Provide preclinical support and evaluation of drug candidates in development programs. Close interaction with individual research and development groups, and effective communication with Company R&D leadership. Qualifications include: The candidate should have a PhD or equivalent degree in chemistry, biochemistry or related discipline, a minimum of 5 years of pharmaceutical industry experience and a strong background in ADME and pharmacokinetics/pharmacodynamics as applied in small molecule lead optimization. Exceptional knowledge of metabolic routes of biotransformation, metabolite identification and the chemistry of drug metabolism are required. The candidate should have demonstrated technical knowledge and industrialexperience in multiple DMPK areas and an in depth understanding of the experimental DMPK methodologies and approaches, in vitro and in vivo, utilized in chemical lead optimization. The candidate must be able to work with multiple disciplines in drug discovery and provide exceptional guidance to medicinal chemists in the lead optimization process. The candidate needs the ability to conduct innovative research in DMPK applied to the discovery of novel drug candidates to achieve defined milestones in a fast paced environment. The candidate should have extensive knowledge of preclinical drug development and in the preparation of regulatory documents, e.g. INDs and NDAs. In addition, she/he should be a goal-oriented and effective leader.  Additional requirements include effective mentoring of scientific staff and highly effective organizational and communication skills. The candidate should be self-motivated, with a track record of productivity, demonstrated leadership potential, possess effective interpersonal skills and be team oriented. The preferred candidate would also have experience and knowledge in the CMC arena and drug formulation.
Salary Range: NA
Minimum Qualification
5 - 7 years

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